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Inflamma on: A clinical trial published in the Journal of Pharmacology and Pharmacotherapeu cs compared the an -inflammatory ac vity of Serrapeptase and Diclofenac (NSAID) in rats and discovered an almost equivalent effect, with Serrapeptase reducing inflamma on 68% and Diclofenac 72%. Serrapeptase was also demonstrated to reduce histamine in the study. Our bodies have a love-hate rela onship with inflamma on. On the one hand, inflamma on is a natural response necessary to protect the body from invading organisms and is necessary for repairing ssues. On the other hand, excessive, or chronic inflamma on can limit joint func on, and destroy bone, car lage and other joint structures. Serrapeptase may be of help for excessive inflamma on by thinning and draining the fluids formed from injuries. A clinical trial out of the Indian Journal of Pharmaceu cal Sciences in 2008 studied the effect of proteoly c enzymes and aspirin on swelling (edema) induced by inflamma on in rats and found a 62.81% reduc on with Serrapeptase, bea ng out trypsin, chymotrypsin, and aspirin. One of the other ways Serrapeptase reduces inflamma on is by dissolving fibrin, as I have men oned. Reduced fibrinolysis, and therefore high fibrin levels, was associated with rheumatoid arthri s in the journal Nature in 2012. In addi on, one study out of the Journal of Immunology in 1995 showed that fibrin induces the expression of the pro-inflammatory cytokine IL-1 beta which in excessive amounts has been implicated in the degenera on of car lage and collagen. Another study out of the same journal of the same year showed that fibrin induced leukocyte chemotac c factor and IL-8 in vivo. These are hallmarks of chronic and acute inflamma on. This suggests that Serrapeptase, with its potent fibrinoly c ac vity may be of use for some kinds of inflamma on. Pain Reduc on: While Serrapeptase reduces inflamma on, one of its most profound benefits is reduc on of pain, due to its ability to block the release of pain-inducing amines such as bradykinin from inflamed ssues. Bradykinin raises intracellular calcium levels and causes the release of glutamate which may over- excite the nervous system crea ng more pain and the poten al for cell death. Lowering bradykinin levels may calm the nervous system and protect cells. The beneficial circulatory effect may assist with pain management as well. Researchers showed that pa ents with long-term lower back pain had constricted blood flow, and those with high cholesterol appeared to suffer with more severe symptoms. Those with narrowed arteries appear about 8.5 mes more likely to have suffered from chronic back pain than those without narrowed arteries. So, Serrapeptase with its clot dissolving ac on may be of some help. The best-selling joint pain supplement in the health food industry is Terry Naturally Curamin, which contains only 4 ingredients and one of those ingredients is a proteoly c enzyme. It has won 28 awards since its crea on. Obviously these enzymes are assis ng very well with pain relief. Carpal Tunnel Syndrome: A small trial of 20 people out of Sawai ManSingh Medical College and Hospital in India studied the effects of carpal tunnel syndrome over the course of 6 weeks. Par cipants took 10mg of Serrapeptase twice daily. At the end of the study, 65% of the par cipants showed significant improvement. No significant side effects were observed. Before ge ng your hopes up too much, there are a few important things to know before taking Serrapeptase. Many of the studies on Serrapeptase are for short term use. Fibrin and plaque, while contribu ng to clots and strokes, do play an important role in protec ng your blood vessels from rupture. Taking high doses of Serrapeptase long term and stripping too much plaque and fibrin out of your body without providing the proper raw materials to create new healthy ssue to replace the plaque and without doing things to Page 48 | Abby's Magazine - www.AbbysMag.com