Volume 2 Issue 5

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Page 16 | Abby's Magazine - Sea cucumber induced apoptosis in pancreatic cancer cells Sea cucumber inhibits the proliferation and induces apoptosis in pancreatic cancer cells. It also induced cell cycle arrest. • Annals of the New York Academy of Sciences. 2008; 1138:181-98. • Journal of Medicinal Food. 2008; 11(3): 443-53. Sea cucumber inhibits human breast cancer cell survival, migration, invasion, and the growth of breast tumor xenografts Frondoside A from sea cucumber exhibits potent anti- metastatic activity. When given intraperitoneally to mice bearing mammary gland implanted mammary tumors, it inhibited spontaneous tumor metastasis to the lungs. Sea cucumber has an anti-invasive effect in human breast cancer cells by inhibiting TPA-induced MMP-9 activation via NF-kB and AP-1 signaling. • European Journal of Pharmacology. 2011; 668(1-2): 25-34. • Breast Cancer Research and Treatment. 2012; 132(2): 1001-1008. • International Journal of Oncology. 2012: 41(3): 933-40. Triterpenoids of marine origin as anti-cancer agents Triterpenoids glycosides from sea cucumbers exhibited significant cytotoxity against human colorectal carcinoma, adenocarcinomic human alveolar basal epithelial cells (A549), HCT-116, HepG2, and human breast adenocarcinoma (MCF-7) cell lines. Triterpenoid glycosides from sea cucumber exhibited in vitro cytotoxicities similar to or better than that of the potent anticancer drug etoposide in four human tumor cells. Frondoside A and cucumarioside A2-2 isolated from Sea Cucumbers induced apoptosis of human leukemia cells. • Molecules. 2013; 18(7): 7886-909. Sea Cucumber has suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis Sea cucumber inhibited cell migration, invasion and angiogenesis in a time-and-concentration- dependent manner. Sea cucumber enhanced inhibition of lung tumor growth induced by Cisplatin. Sea cucumber alone shrank NSCLC tumors by 40% in vivo while chemotherapy only shrank tumors 47%. The combination of sea cucumber and chemotherapy shrank tumors by 68%. In vitro tests showed that sea cucumber inhibited various cancer cell lines: breast cancer cells by 95%, melanoma cells by 90%, liver cancer cells by 95% and three types of lung cancer cells by 85-88%. •PLoS One. 2013: 8(1); e53087. Research on Sea Cucumber ANGIOSTOP

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