Volume 10 Issue 4

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Page 2 of 31 | # 51| Page 3 It's summer! The good news is that your immune system will have less on its plate than during the cold, wet months of winter. The bad news is there are still plenty of immune challenges this time of year. And if your immune system is sensitive to grass pollen or ragweed, summer can be pretty miserable. Ditto if you live in a part of the country where wildfire smoke is just an expected part of life now. Fortunately, a few natural ingredients can help. N-Acetyl-L-Cysteine is an antioxidant amino acid that raises blood levels of glutathione. That's an important role, because glutathione is the body's master antioxidant and a key player in healthy immune function. Taking NAC elevates glutathione more effectively than taking glutathione itself. That's because NAC supplements go directly into the bloodstream, whereas glutathione supplements get broken down in the digestive tract. This allows NAC to scavenge free radicals, reduce oxidative stress, recycle other antioxidants, and support immunity. NAC also supports a healthy inflammation response by inhibiting cytokines and supports lung function by breaking up mucoproteins. Quercetin is an antioxidant bioflavonoid found in many fruits, such as elderberry and citrus. It has multiple functions. Quercetin helps reduce oxidative stress by neutralizing free radicals and supports a healthy inflammation response. , It also boosts the activity of other immune-supporting nutrients, such as vitamin C, zinc and vitamin D. , Finally, quercetin regulates the body's response to pollutants.* The main drawback of quercetin is its poor bioavailability, so if you're looking for a quercetin product, you need to choose carefully. We recommend the following immune and respiratory supplements from Natural Factors: NAC. This is a high-quality pharmaceutical grade amino acid product. We like that the 600-mg strength is the same dose used in human clinical research. Lung, Bronchial & Sinus Health. This is a comprehensive formula to nourish and support the whole respiratory system. It features NAC, along with the herbal ingredients bromelain, marshmallow, mullein, wild cherry bark, horehound, and ivy leaf extract. These ingredients have been shown to support clear airways, loosen respiratory tract secretions and expel them from the body, promote lung capacity, soothe mucosal linings, and promote a healthy inflammation response. Quercetin LipoMicel Matrix. Quercetin is fat-soluble, so it has limited solubility in the watery environment of the digestive tract. The patent-pending technology LipoMicel creates a liquid micelle matrix to disperse quercetin into microdroplets that are easier to absorb. A bioavailability study found Quercetin LipoMicel Matrix stays in the bloodstream longer than other forms of quercetin and leads to up to 10x higher absorption. References 1 David AVA, Arulmoli R, Parasuraman S. Overviews of biological importance of quer- cetin: a bioactive flavonoid. Pharmacogn Rev. 2016 Jul-Dec;10(20):84-89. https://www. 2 Askari G, et al. The effect of quercetin supplementation on selected markers of inflam- mation and oxidative stress. J Res Med Sci. 2012 Jul;17(7):637-41. https://pubmed. 3 Colunga Biancatelli RML, et al. Front Immunol. 2020 Jun 19;11:1451. https://pubmed. 4 Lee KY, et al. Quercetin directly interacts with vitamin D receptor (VDR): structural implication of VDR activation by quercetin. Biomol Ther. 2016 Mar 1;24:191-8. https:// 5 Soulnier J, et al. Quercetin LipoMicel—a novel delivery system to enhance bioavail- ability of quercetin. J Nat Health Prod Res. 2021 Jul-Dec;3 (2):1-8. https://jnhpre- Supplements for IMMUNITY and RESPIRATORY HEALTH

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