Issue link: https://cp.revolio.com/i/800850
Estrogen receptors In order for estrogen to func on, it needs to a ach to a receptor. Once this binding occurs, it determines how a cell will func on for the rest of its life. Estrogen receptors exist in many ssues of the body, explaining the many condi ons associated with estrogen. They are classified into two types: estrogen receptor alpha (ER- alpha) and estrogen receptor beta (ER-beta). Each type of receptor has different effects in terms of cell prolifera on and how it responds to E1, E2 or E3. The estrogen receptor alpha (ER-alpha) is s mulated by E1 and E2 and is considered prolifera ve and pro-carcinogenic. It is found in the following ssues: • Blood vessels • Hypothalamus • Ovaries • Breast • Liver • Prostate • Endometrium • Lung • Testes The estrogen receptor beta (ER-beta), on the other hand, is s mulated by E2 and E3 and is considered an -prolifera ve and an -carcinogenic. It is found in these ssues: • Blood vessels • Kidney • Prostate • Breast • Heart • Skin • Brain • Intes nes • Endothelial cells • Bone • Lung Since estrogen receptors are distributed widely in the body, estrogen is clearly in many different health condi ons. It has been implicated in the pathogenesis of some types of cancer, including breast, endometrial, ovarian, prostate and tes cular cancer. This is partly due to the expression of ER-alpha and ER-beta in these types of ssues. Recently, new studies show that estrogen may also play a role in lung cancer and melanoma. Knowing the func on and distribu on of estrogen receptors is vital to achieving the right balance of E1, E2 and E3. Since the prolifera ve and pro-carcinogenic ER-alpha Page 18 | Abby's Magazine - www.AbbysHealthAndNutrition.com