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Key Benefits of WellBetX Berberine Helps maintain healthy blood sugar balance Supports healthy insulin sensitivity Helps maintain cardiovascular health Supports healthy weight management Helps reduce the digestion of carbohydrates How It Works Berberine supports healthy blood-glucose levels and insulin sensitivity through various physiological mechanisms. Most of its actions involve AMP-activated protein kinase (AMPk). AMPk is found inside every cell and serves as a "master regulating switch" in energy metabolism. By affecting AMPk, berberine helps to induce the uptake of glucose into cells, where it is converted into energy. Activating AMPk is also key to berberine's function in maintaining healthy blood lipid levels already within the normal range, such as LDL cholesterol, total cholesterol, and triglycerides. It also helps burn fatty acids within cells, stabilize the receptors for LDL cholesterol, and helps maintain healthy lipid formation by the liver. Berberine also helps reduce the digestion of carbohydrates, including starch, by inhibiting disaccharidases – the enzymes needed to break them down. As a result, only a limited amount of glucose can be absorbed through the intestines and pass into the blood. For the glucose that is absorbed into the bloodstream, berberine helps get it into cells efficiently by supporting the transport proteins responsible for moving it across cell membranes. It also supports healthy insulin sensitivity by supporting the number and activity of available insulin receptors. This allows the same concentration of insulin to be effective at moving glucose out of the bloodstream. Using insulin efficiently is a foundation for supporting healthy blood sugar levels. To learn more about WellBetX Berberine, visit naturalfactors.com! Berberine for Blood Sugar & Cardiovascular Support By Michael T. Murray, N.D. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. One of the most exciting natural products in current research is berberine, an alkaloid found in goldenseal root, barberry bark, Oregon grape root, and coptis (goldthread) root. What is so exciting about the research is that clinical trial results show it supports healthy blood sugar, triglyceride, and cholesterol levels already within the normal range. Alkaloids like berberine are synthesized in plants to serve vital roles in the plant's cellular metabolism. Obviously, humans can also gain benefits from these compounds. Since early human times, plant alkaloids have been among the most important health-supporting agents used by humans. Berberine-containing plants have been revered for a number of clinical applications through the years. One of its most important uses is for supporting healthy blood sugar balance. Every vegetarian capsule of WellBetX® Berberine from Natural Factors® provides 500 mg of berberine, the same potency successfully used in clinical trials to support insulin sensitivity and prompt an effect that supports weight management. By supporting healthy blood sugar levels already within the normal range, berberine supports the body's healthy production of insulin, the fat-storing hormone.