Volume 9, Issue 3

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Page 18 | Abby's Magazine | Findings from a new University of Kentucky College of Medicine and College of Health Sciences study add to growing evidence that resistance exercise has unique benefits for fat loss. The Department of Physiology and Center for Muscle Biology study 1 published in the FASEB Journal found that resistance-like exercise regulates fat cell metabolism at a molecular level. The study results in mice and humans show that in response to mechanical loading, muscle cells release particles called extracellular vesicles that give fat cells instructions to enter fat-burning mode. Extracellular vesicles were ini ally understood as a way for cells to selec vely eliminate proteins, lipids and RNA. Recently, scien sts discovered that they also play a role in intercellular communica on. The study adds a new dimension to how skeletal muscle communicates with other ssues by using extracellular vesicles, says John McCarthy, Ph.D., study author and associate professor in the UK Department of Physiology. "To our knowledge, this is the first demonstra on of how weight training ini ates metabolic adapta ons in fat ssue, which is crucial for determining whole-body metabolic outcomes," McCarthy said. "The ability of resistance exercise-induced extracellular vesicles to improve fat metabolism has significant clinical implica ons." Ivan J. Veche , Bailey D. Peck, Yuan Wen, R. Grace Walton, Taylor R. Valen no, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Walden, Björn Alkner, Charlo e A. Peterson, John J. McCarthy. Mechanical overload-induced muscle-derived extracellular vesicles promote adipose ssue lipolysis. The FASEB Journal, 2021; 35 (6) Exercise Improves the Brain The scien sts had a hypothesis: endurance training changes the ac vity of gene enhancers in skeletal muscle by remodeling the processes. They discovered that a er comple ng an endurance training program, their training subjects' enhancers in the skeletal muscle had been altered. They were able to connect the many enhancers that exhibited this altera on to gene c databases to discover that many of them have been iden fied as hotspots of gene c varia on between individuals - hotspots that have been associated with human disease. In par cular, they found that exercise remodels enhancer ac vity in skeletal muscle that are linked to cogni ve abili es, which opens for the iden fica on of exercise training-induced secreted muscle factors targe ng the brain. B U R N S FAT By Douglas Perry How Lifting Weights

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