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and DIABETES Vitamin D Supplementa on results in improved Vitamin D levels, be er glycemic control in diabe cs. The September 1, 2017 issue of The Journal of Clinical Endocrinology & Metabolism published the results of a meta-analysis that adds evidence to an associa on between be er glycemic control among diabe cs and higher vitamin D levels resul ng from supplementa on. The meta-analysis included 24 controlled trials that included a total 1,528 individuals with type 2 diabetes who received a placebo or vitamin D with or without calcium for at least two months. Serum 25-hydroxyvitamin D levels and at least one measure of glycemic control, including hemoglobin A1c, (HbA1c, a marker of long term glucose control), fas ng plasma glucose and HOMA-IR (which assess insulin resistance), were measured at the beginning and end of each trial. All but one trial found a significant increase in serum vitamin D among those who received the vitamin. Supplementa on with 4,200 interna onal units (IU) vitamin D per day was associated with an average increase in serum 25-hydroxyvitamin D levels of 17 nanograms per milliliter (ng/ mL). Hemoglobin A1c levels declined by an average of 0.3% in vitamin D supplemented par cipants. The addi on of calcium to vitamin D was associated with an even greater decline. Among par cipants who received vitamin D, fas ng plasma glucose decreased by an average of 4.9 milligrams per deciliter (mg/dL). Insulin resistance also improved in vitamin D-supplemented par cipants. The authors suggest that glucose homeostasis is enabled by vitamin D supplementa on and/or sun exposure that results in serum 25-hydroxyvitamin D concentra ons of at least 40 ng/mL. (Life Extension suggests an op mal 25-hydroxyvitamin D range of 50-80 ng/mL.) "Our meta-analysis found that vitamin D supplementa on and subsequent increased serum 25-hydroxyvitamin D levels improved glucose control and insulin resistance in type 2 diabe c pa ents," the authors conclude. "Overall, vitamin D supplementa on seems to be efficacious as an adjuvant treatment of diabetes-related glucose metabolism disorders. The results of the current meta-analysis suggest that a minimum dose of 4000 IU/ day, which is equivalent to the tolerable upper intake level of vitamin D for adults, is required to have a protec ve effect on glucose homeostasis in type 2 diabe c pa ents." Page 8| Abby's Magazine - www.AbbysMag.com