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Abby's Magazine - Volume 5 Issue 4 | Page 23 can have one or two varia ons in either. In fact, SNPs are incredibly common – about 30-45% of the popula on has one SNP in one or the other, and 10% of us have two varia ons in one or the other. If you have one change in either gene, this is referred to as your being heterozygous for the SNP (o en notated as +/-); if you have two changes in either gene, you are considered homozygous for that SNP (o en wri en as +/+). So, you can be either +/- or +/+ for A1298C, and/or +/- or +/+ for C677T. One or even two changes in A1298C usually doesn't usually lead to any health or medical consequences, though it merits awareness, while changes in C677T can, with two changes presen ng the greatest likelihood of poten al risk. Emphasis on the word poten al – which I'll come back to shortly. Medically, because of the importance of adequate amounts of circula ng folate, because of the poten al harms of excess circula ng homocysteine, and the hazards of methyla on not properly occurring, the MTHFR C677T SNP has been associated with increased risks of the following: • Vascular disease, high blood pressure, heart disease, cogni ve dysfunc on and demen a (including Alzheimer's). • Clo ng disorders leading to excessive clo ng (also increasing demen a and stroke risk). • Glaucoma. • Depression, anxiety, and psychiatric disorders, as well as decreased response to an depressant medica ons. • Fer lity problems, miscarriage, Pregnancy Induced Hypertension (PIH), pre-eclampsia, and placental abrup on. • Intrauterine development of neural tube defects including anencephaly, spina bifida, and cle lip and palate. • Vitamin B12 deficiency which can cause megaloblas c anemia, fa gue, weakness, cons pa on, loss of appe te, weight loss, neurological changes such as numbness and ngling in the hands and feet, difficulty maintaining balance, depression, confusion, demen a, poor memory, and soreness of the mouth or tongue. Should You Get Tested? And What Tests? Conven onal tes ng is readily available for the MTHFR SNPs themselves, and, also for plasma homocysteine, B12, and folate levels. Any licensed provider can order these for you – though they are not necessarily all covered by insurance. Independent labs such as Genova and Doctor's Data also offer these labs; I recommend reviewing your results with a knowledgeable medical prac oner before Combines highly effective herbs and through a new, state-of- the-art process infuses the essences of these same botanicals into the crystalline structure of the aqueous medium. n-fuzed Testosterone has been clinically tested and shown to raises testosterone levels in 30-60 days*. For men only. Promotes testosterone in the normal range Clinically Tested * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. For more information please visit: HarmonicInnerprizes.com or Call 1.888.667.4300 Available in: 8 fl. oz 16 fl. oz Discover Your Inner Harmony Available in: 8 fl. oz 16 fl. oz Combines highly effective herbs that have been clinically shown to balance hormone levels and helps the body minimize symptoms normally associated with menopause and through a new, state-of-the-art process infuses the essence of these botanicals into the crystalline structure of the aqueous medium*. For women only. Promotes hormonal balance Clinically Tested Now Available at Abby's Health & Nutrition (813) 265-4951 abbyshealthandnutrition.com ••• 25% OFF till August 31, 2017