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Abby's Magazine - May / June 2014 | Page 15 SAMe (S-Adenosyl Methionine) SAMe has an extended positive record of proven benefits for the brain, as well as for the liver, digestive system, and joints. SAMe has been tested as a dietary supplement in well over 40 double-blind trials. Potent Promoter Of Healthy Mood SAMe strongly promotes healthy mood, as confirmed from at least 18 clinical trials published over almost four decades. Individuals who have mood difficulties also often have problems with memory and other cognitive functions. SAMe supports many of the metabolic processes known to sustain memory. Studies indicate that some individuals with cognitive challenges have low SAMe in the brain. Supplementing with SAMe readily elevates its levels in the brain. SAMe Dietary Supplements After much research and development work, excellent SAMe supplements are now available in the form of enteric- coated tablets packaged in blister packs. These ensure that SAMe will survive the stomach acid to reach the intestine, where it can be absorbed. SAMe is available in 200 and 400 mg tablets. Intakes of up to 1600 mg may be useful, as directed by a competent healthcare professional. It is important to take SAMe at least one hour away from meals, and to avoid chewing or crushing the enteric-coated tablet so that it can survive passage through the stomach. Individuals with bipolar disorder are advised to avoid SAMe supplementation as it may aggravate the manic phase.